Studies on mikamycin B lactonase. II. Stabilization of mikamycin B lactonase.
نویسندگان
چکیده
منابع مشابه
Studies on mikamycin B lactonase. I. Degradation of mikamycin B by Streptomyces mitakaensis.
Some intensive studies on the inactivation mechanisms of clinically important antibiotics such as penicillin1), chloramphenicol2) and aminoglycosidic antibiotics3,4) have been reported. Derivations and cleavages of these antibiotic molecules were the mechanisms of inactivation in resistant organisms. Another aspect of antibiotic inactivation so far studied is the action of soil microbes. ARGOUD...
متن کاملChromophore activating enzyme involved in the biosynthesis of the mikamycin B antibiotic etamycin from Streptomyces griseoviridus.
A 3-hydroxypicolinic acid activating enzyme from etamycin producing Streptomyces griseoviridus has been purified to apparent homogeneity. Etamycin is a member of mikamycin B antibiotics, chromopeptide lactones, which contain 3-hydroxypicolinic acid (3-HPA) as the chromophoric group. The enzyme catalyzes both the 3-HPA-dependent ATP-pyrophosphate exchange and the formation of 3-HPA adenylate fro...
متن کاملNew Insight in Human Lactonase PON2
It is well established that oxidative stress from mitochondria plays an important role in apoptosis and also leads to premature aging and cancer [1]. There is growing scientific consensus that proteins with antioxidative functions, such as paraoxonases, can lower the incidence of these diseases. The paraoxonase (PON) gene family consists of three members: PON1, PON2, and PON3. PON genes are loc...
متن کاملSTUDIES ON HEPATITIS B VACCINES
HBs vaccines were prepared by three different methods: 1) Heat inactivation (Krugman, et.al 1971)2) Ammonium sulphate precipitation followed by column chromatography (Sephadex G-200) 3) PEG-6000 (polyethylene glycol) precipitation followed by column chromatography using Sephadex G-200. Their efficacy was studied in guinea pigs, and the results compared with commercial Japanese vaccine (Gr...
متن کاملNew Insights into the Binding and Catalytic Mechanisms of Bacillus thuringiensis Lactonase: Insights into B. thuringiensis AiiA Mechanism
The lactonase enzyme (AiiA) produced by Bacillus thuringiensis serves to degrade autoinducer-1 (AI-1) signaling molecules in what is an evolved mechanism by which to compete with other bacteria. Bioassays have been previously performed to determine whether the AI-1 aliphatic tail lengths have any effect on AiiA's bioactivity, however, data to date are conflicting. Additionally, specific residue...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Agricultural and Biological Chemistry
سال: 1975
ISSN: 0002-1369,1881-1280
DOI: 10.1271/bbb1961.39.1673